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Metformin contains no GLP-1 activity whatsoever, making it fundamentally different from modern peptide-based therapies that directly target appetite centers in the hypothalamus

Deficiency is rare in developed countries but is most common among people who follow diets lacking in food variety, especially those dominated by rice, white potatoes, and cassava

Psychopharmacology , 143 , 309-314

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Marrs, K